Agilent Technologies Varian 320-MS LC/MS Manual de usuario

Varian 320-MS LC/MS

Quadrupole Mass Spectrometer

Pre-installation Instructions

9300025700: Rev. A 1of 14 Pre-installation Instructions

Checklist

NOTE: Do not unpack the shipping cartons.

Check off each checklist box after satisfying each requirement as described in the instructions. All requirements

must be met before requesting installation.

NOTE: If the site is not ready for installation when the Varian Representative arrives, Varian, Inc.

reserves the right to invoice for the Representative’s time.

REQUIREMENTS ;

Installation site is in compliance with all relevant safety regulations. 

User Representative will be available during the installation and certification period. 

Entrance to the installation site is at least 92 cm (36 in.) wide. 

Bench space is sufficient. 

Bench can support system weight.

320-MS with 460-LC, at least 114 kg (250 lb)

320-MS with HTS PAL, at least 103 kg (231 lb)



Bench does not vibrate. 

Exhaust system is suitable. 

Temperature maintained between 16 and 30 °C, (61-86 °F). 

Relative humidity maintained between 20 and 80%. 

Installation site is free of excessive particulate matter. 

Specified electrical supply and power outlets are installed. 

Nitrogen gas (at least 99% pure), regulator, and gas lines are installed. 

Air (less than 0.1 ppm hydrocarbons), regulator, and gas lines are installed. 

Argon (greater than 99.0% pure), regulator, and gas lines are installed. Argon required only for

triple quadrupole instruments. 

Materials and solvents of specified grade are on site. 

Shipping cartons examined for damage. If there was any damage, the conditions were reported. 

Requesting Installation

After preparing the site, contact the Customer Service office in your region to schedule installation.

NOTICE: This document contains references to Varian.

Please note that Varian, Inc. is now part of Agilent

Technologies. For more information, go to

www.agilent.com/chem.

9300025700: Rev. A 2of 14 Pre-installation Instructions

Contents

Introduction ...................................................................2

Safety ......................................................................2

Before the Installation ...................................................3

User Representative................................................3

Entrance ..................................................................3

Bench Space and Load ...........................................3

Vibration ..................................................................6

Temperature ............................................................7

Humidity...................................................................8

Particulate Matter ....................................................8

Power Requirements .............................................. 8

Installation Site Power .......................................... 10

Qualified Computer Equipment............................. 11

Gas Requirements ................................................ 11

Materials and Solvents.......................................... 12

When the LC/MS Arrives............................................ 13

Inspecting the Shipping Cartons........................... 13

Unpacking and Installing....................................... 14

Spare Parts ................................................................ 14

Preventive Maintenance............................................. 14

Introduction

The Pre-installation Instructions are a guide for each requirement of the checklist. Follow these

instructions to ensure that the installation requires no more than the usual three days. Have the

completed checklist available to schedule the installation. After the Varian Representative

completes the installation, and it is accepted, samples can be analyzed.

After meeting all of these requirements, contact the Customer Service office in your

region to schedule the installation.

The LC/MS operates reliably under carefully controlled environmental conditions. You must

provide suitable power sources, operating environment, materials, and solvents. Failures may

occur if you use or maintain the system outside of the power and operating environment ranges

and limits described in these instructions. The Varian Warranty and Service contract specifically

excludes the repair of failures due to such causes.

CAUTIO

All phases of preparing the installation site must conform to

local safety, electrical, and building codes. These codes take

precedence over any recommendations in these instructions.

The customer is responsible for compliance.

Safety

Safety is the most important consideration for instrument use. Determine if the installation site

complies with all relevant safety regulations.

;Check the checklist box: Installation site is in compliance with all relevant

safety regulations.

9300025700: Rev. A 3of 14 Pre-installation Instructions

Before the Installation

User Representative

Schedule the installation when the User Representative will be available. One of the important

duties of the Varian Representative is to familiarize the User Representative with the basic

functions of the LC/MS.

;Check the checklist box: User Representative will be available during the

installation and certification period.

Entrance

Before arranging delivery of the LC/MS, determine that there is sufficient clearance to move the

shipping cartons to the installation site. The largest shipping carton is 72 cm (28 in.) wide by

92 cm (36 in.) long. If the cartons are to be moved with the pallet, at least 92 cm (36 in.)

clearance is needed. Allow additional room for maneuvering the shipping containers around

corners and through doors.

;Check the checklist box: Entrance to the installation site is at least 92 cm

(36 in.) wide.

CAUTIO

The MS, foreline pumps, and LC are heavy. To prevent

personal injury, use appropriate moving and lifting

techniques.

Bench Space and Load

Use the following information to plan the layout of your LC/MS system. The Varian

Representative will unpack the cartons and put the modules on the bench.

Figure 1 shows a possible layout for the LC/MS with the 212-LC pumps and the 460-LC

AutoSampler. Tables 1 and 2 provide information about the bench.

Figure 2 shows a possible layout for the LC/MS with the 212-LC pumps and the HTS PAL

AutoSampler. Tables 3 and 4 provide information about the bench.

The bench must be strong enough to support the weight of all modules, wide enough for all

modules, and at least 84 cm (33 in.) deep for the MS.

9300025700: Rev. A 4of 14 Pre-installation Instructions

LC/MS with 212-LC and LC-460

Figure 1 shows a possible layout for the LC/MS with the 212-LC pumps and the

460-LC AutoSampler.

Figure 1 Suggested Layout with 212-LC and 460-LC

Table 1 and Table 2 provide information about the modules in Figure 1.

Table 1 Bench Width with the 460-LC

Bench

Width 212-LC 460-LC MS CPU Monitor and

Keyboard Total

cm 26 30 53.5 18.7 51 178 cm

in. 10.5 12 21 7.5 20 71 in.

Table 2 Bench Load with the 460-LC

Bench

Load 212-LC 460-LC MS CPU

Monitor and

Keyboard Total

kg 14.5

without cooling 19

with cooling 21 61 11.5 5.5 without cooling 111.5 kg

with cooling 113.5 kg

lb 32

without cooling 42

with cooling 46 134 25.3 11.5 without cooling 245 lb

with cooling 250 lb

9300025700: Rev. A 5of 14 Pre-installation Instructions

212-LC and HTS PAL

Figure 2 shows a possible layout for the LC/MS with 212-LC pumps and CTC HTS PAL

Autosampler.

Figure 2 Suggested Layout with 212-LC and HTS PAL

Table 3 and Table 4 provide information about the modules in Figure 2.

Table 3 Bench Width with the HTS PAL

Bench

Width 212-LC MS with HTS PAL CPU Monitor and

Keyboard Total

cm 26 53.5 18.7 51 150 cm

in. 10.5 21 7.5 20 59 in.

Table 4 Bench Load with the HTS PAL

Bench

Load 212-LC MS with HTS PAL CPU Monitor and

Keyboard Total

kg 14.5 71 11.5 5.5 102.5 kg

lb 32 162 23.5 11.5 231 lb

The system requires a clean, flat bench. The bench must be strong enough to support the

weight of the modules. The area under the bench must be large enough for the foreline pump. If

the bench is against a wall, drill a hole large enough for the vacuum tubing of your pump

through the rear of the bench. The area under the bench must be large enough for the height of

the foreline pump, see Table 8. If the bench is higher than 92 cm (36 in.) place a vibration-

isolation bench under the foreline pump. The vibration–isolation bench must be capable of

supporting the foreline pump.

Plan to put the monitor and keyboard on the same bench as the LC/MS. If the plan is to use a

separate bench, position them within 3 m (10 ft) of the rear of the LC/MS. The CPU can go on

or under the bench.

9300025700: Rev. A 6of 14 Pre-installation Instructions

Table 5 Additional Bench Space Requirements

Function Space Allowance

Provide space for air circulation, gas

lines, and electrical connections. 15 to 30 cm (6 to 12 in.) behind the system.

Dissipate room heat and allow for

routine maintenance. At least 76 cm (30 in.) above the system.

Analytical Systems only:

Provide space for solvent bottles. At least 30 cm (12 in.) to side of the LC.

Please refer to the Varian LC Systems Pre-installation Instructions, part number 391483100, for

information about LC modules.

Use Table 6 and Table 7 to determine the required width of the bench and the weight the bench

must support for your configuration.

Regardless of configuration, the depth of the bench depends on the clearance between the

bench and the wall to accommodate the vacuum hoses for the foreline pumps.

•If the distance between the bench and the wall is greater than or equal to 10.2 cm

(4 in.) then the bench must be at least 84 cm (33 in.) deep. The vacuum hoses will have

sufficient room to connect the MS to the foreline pump.

•If the distance between the bench and the wall is less than 10.2 (4 in.) then the bench

must be at least 94 cm (37 in.) deep. To accommodate the vacuum hoses, two 5.8 cm

(2.3 in.) holes must be drilled into the bench on the left side and to the rear of the MS

location.

Table 6 Bench Width Worksheet

Bench

Width ___-LC Auto-

sampler Other

Components MS CPU

Monitor and

Keyboard Total

cm ______ ______ ______ 53.5 18.7 51 ___cm

in. ______ ______ ______ 21 7.5 20 ____in.

;Check the checklist box: Bench space is sufficient.

Table 7 Bench Load Worksheet

Bench

Load ___-LC Auto-

sampler Other

Components MS CPU

Monitor and

Keyboard Total

kg ______ _______ ______ 61 11.5 5.5 ____kg

lb ______ ______ ______ 134 25.3 11.5 ____lb

;Check the checklist box: Bench can support system weight.

320-MS with 460-LC, at least 114 kg (250 lb)

320-MS with HTS PAL, at least 103 kg (231 lb)

Vibration

Ensure that the benches are free from vibrations, especially those caused by equipment in

adjoining locations. Because the foreline pump vibrates during operation, it belongs on the floor

below the LC/MS, not a on the bench with the LC/MS.

;Check the checklist box: Bench does not vibrate.

9300025700: Rev. A 7of 14 Pre-installation Instructions

MS40+ Foreline Pump

Table 8 MS40+ Foreline Pump Details

Item Information

Diameter of hole in bench, if needed 5.8 cm (2.3 in.)

Width 29.7 cm (11.8 in.)

Depth 41.8 cm (16.5 in.)

Height 22.8 cm (9 in.)

Vacuum hose length 1.8 m (6 ft)

Power cord length 2.5 m (8 ft)

Serial cable length 2.7 m (9 ft)

Dedicated circuit 1 circuit which can provide, 200-240V ac, 50-60 Hz, 10A

Power cord plug CEE 7/7 or NEMA 6-15P

Exhaust System

Do not put the foreline pump in an enclosed space. The foreline pump exhaust most

compounds introduced into the MS and small amounts of oil vapor.

Provide an adequate fume exhaust system for the outlet of each foreline vacuum pump. Each

foreline pump must be vented at least 2 L/min. The API spray chamber must be vented at least

20 L/min to a separate vent line. Ensure that the exhaust system does not pull a vacuum on the

API chamber. Consult local regulations for the proper method of exhausting the fumes.

;Check the checklist box: Exhaust system is suitable.

Temperature

The optimal operating temperature is between 16 and 30 °C (61-86 °F).

NOTE: As installation site temperature increases, system reliability decreases due to heat

generated by electronic components during operation. This heat must dissipate to the

surrounding air for reliable operation.

The airflow around the system must be adequate. The air-conditioning system must maintain a

constant temperature (within the operational limits) around the system. Do not place the system

near air ducts, windows, or heating and cooling systems. The average steady-state heat load

for the MS alone is 6,000 Btu, with a possible short-term heat dissipation of 15,000 Btu during

startup.

;Check the checklist box: Temperature maintained between 16 and 30 °C

(61-86

F).

9300025700: Rev. A 8of 14 Pre-installation Instructions

Humidity

The relative humidity of the operating environment must be between 20 and 80%, with no

condensation. Operating the LC/MS at a very low humidity may result in the accumulation and

discharge of static electricity, shortening the life of electronic components. Operating the

system at high humidity may create condensation and result in short circuits.

Varian recommends using a combination temperature and humidity monitor in your installation

site.

;Check the checklist box: Relative humidity maintained between 20 and 80%.

Particulate Matter

Your installation site must not have excessive dust, smoke, or other particulate matter.

Particulate matter may block airflow vents causing the electronics to overheat.

;Check the checklist box: Installation site is free of excessive particulate matter.

Power Requirements

212-LC

Power Input: 85-264V ac; 47-63 Hz; 60 Watts; 100 VA

460-LC

The 460-LC requires 95-240V ac± 10%; 50 - 60 Hz; 200 VA.

216-LC

115V ac; +15/-20%; 50/60 Hz; 250 VA

230V ac; +15/-20%; 50/60 Hz; 250 VA

(For UPS, assume 250W)

For 115V ac: one 5.0 AT-fuse (5 x 20 mm, IEC 127)

For 230V ac: one 2.5 AT-fuse

All fuses supplied with the 216-LC instrument are UL-listed and CSA-certified.

The 216-LC must be used with appliances and power sources that have the proper protective

grounding.

The MS requires a separate circuit, and the outlet must have adequate amperage capacity and

a reliable ground. The power source must be clean and capable of providing up to 220-240V ac,

50/60 Hz ±3 Hz, 1.0 kW.

9300025700: Rev. A 9of 14 Pre-installation Instructions

LC/MS

The LC/MS requires the following.

Table 9 LC/MS Circuits, Power Plug and Outlet Types

Component Circuit Power Plug and Outlet Type

320-MS 1 each 220V US: 1 each NEMA 6-15P

EU: 1 each CEE 7/7 plugs

MS40+ Foreline

Pump

1 each 220V US: 1 each NEMA 6-15P

EU: 1 each CEE 7/7 plugs

Computer 110V or 220V, see appropriate user manual

LC modules 110V or 220V see appropriate user manual

Table 10 LC/MS Power Requirements

Module Max Current Draw (Amps)

320-MS 10A

MS40+ Foreline Pump 10A

Use a separate dedicated power source for HPLC modules and additional instruments and

equipment. Never plug the mass spectrometer and the chromatograph into the same power

source or the power source may overload. Never use the free outlet on any of the power

sources for equipment that draws more than 2A.

Table 11 MS and Foreline Pump Power Cords

Power Cord 320-MS MS40+ Foreline Pump

Length 1 each 2.5 m (8 ft) 1 each 2.5 m (8 ft)

Plug US: 1 each NEMA 6-15P

EU: 1 each CEE 7/7 plugs

US: 1 each NEMA 6-15P

EU: 1 each CEE 7/7 plugs

The power cables for the CPU, monitor, and printer are approximately 2.13 m (7 ft) long.

Figure 3 shows the power plugs and outlet types.

CAUTIO

Replacing or substituting power cords or plugs must be done

with strict compliance with all regulations, including electrical

codes, power cord color coding, and appropriate regulatory

agency certification marks.

9300025700: Rev. A 10 of 14 Pre-installation Instructions

Outlets Plugs

Figure 3 Outlets and Plugs

Installation Site Power

In the United States, the power supply to the installation site must be 200-240V ac for the MS

and the foreline pump and 100-120V ac for the LC, autosampler, computer, printer and other

modules.

In Europe, the power supply to the site must be 200-240V ac,

The power supply must be stable (free of fluctuations due to slow changes in the average

voltage or to changes resulting from surges, sags, or transients). The voltage must meet

EN/IEC 61000-4-5 and EN/IEC 61000-4-11 standards for voltage stability.

A measured ground to neutral potential of greater than 3V ac or V dc indicates grounding

problems that may need correction. Evaluate any power source suspected of having noise

problems with a recording-type power line monitor before operating the system.

NOTE: If concerned about the quality of the power, install an uninterruptible power supply, or a

power conditioner or both, see Table 12.

Table 12 Maximum Power Consumption

Module Maximum Power Consumption

MS without pump 1200 VA

MS with foreline pump 3400 VA

;Check the checklist box: Specified electrical supply and power outlets are

installed.

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