Agilent Technologies Enhancer Cell Manual de usuario

Agilent Enhancer Cell

Operator’s Manual

Notices

Manual Part Number

70-9072 Rev B

February 2020

No part of this manual may be

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or translation into a foreign language)

without prior agreement and written

consent from Agilent Technologies, Inc.

as governed by United States and

international copyright laws.

Agilent Technologies, Inc.

3501 Stevens Creek Blvd.

Santa Clara, CA 95052 USA

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The material contained in this document

is provided “as is,” and is subject to being

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Safety Notices

CAUTION

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hazard. It calls attention to an

operating procedure, practice, or

the like that, if not correctly

performed or adhered to, could

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WARNING

A WARNING notice denotes a

hazard. It calls attention to an

operating procedure, practice, or

the like that, if not correctly

performed or adhered to, could

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Enhancer Cell Operator’s Manual 3

Content

1 Introduction 5

Assembly Components 8

Unpacking Your Enhancer Cell Assembly 9

2 Operation 11

Membrane Selection Information for the Enhancer Cell 14

Ideal Characteristics for a Membrane 14

Examples of Membranes Used for In Vitro Release Tests 14

Content

4 Enhancer Cell Operator’s Manual

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Enhancer Cell Operator’s Manual 5

1Introduction

Assembly Components 8

Unpacking Your Enhancer Cell Assembly 9

1Introduction

6 Enhancer Cell Operator’s Manual

The Enhancer Cell Assembly, designed for research, quality control, and product

development laboratories, is a PTFE cell with adjustable volume and a screw cap

to retain the skin or artificial membrane. The assembly can be used with any

dissolution tester and is available with 4.0, 2.0, or 0.5 cm² surface area. Using the

Paddle-over-Enhancer-Cell method (see Figure 3, “Paddle over Enhancer Cell,” on

page 7) provides release rates comparable to Franz Cell technology. It provides

release rate data for quality control of topicals using readily available dissolution

apparatus, including 200 mL or standard 900 mL dissolution vessels.

The alignment tool (see Figure 1, “Enhancer Cell Assembly,” on page 6) is used to

hold the membrane in place and ensure the washer is centered properly while

using the adjustment tool to set the volume with the adjustment plate. When

purchasing more than one Enhancer Cell Assembly, one alignment tool is

required per size. The adjustment tool is universal and fits all sizes. Both the

alignment tool and the adjustment tool are required and must be ordered

separately. The Enhancer Cell Assembly does not include the vessel, paddle, or

membrane / skin.

Figure 1. Enhancer Cell Assembly

*not provided—for illustrative purposes only.

Retaining Ring

Washer

Membrane or Skin *

Adjustment Plate

with O-ring Cell Body R

Alignment Tool

Adjustment Tool

1Introduction

Enhancer Cell Operator’s Manual 7

Figure 2. Enhancer Cell Assembly Surface Areas

Figure 3. Paddle over Enhancer Cell

0.5 cm² 2 cm² 4 cm²

1Introduction

8 Enhancer Cell Operator’s Manual

Assembly Components

The Enhancer Cell Assembly consists of the following components (see

Figure 1, “Enhancer Cell Assembly,” on page 6):

•Retaining ring – secures the membrane or skin sample to the cell body and

ensures full contact with the sample.

•Washer – provides a leak-proof seal between the membrane, retaining ring,

and cell body.

•Membrane (not provided) – retains the sample in the sample

compartment. Usually an artificial membrane although some tests use

skin samples.

•Adjustment plate – allows control of the volume of the reservoir within the

cell body. This threaded part can be placed at the appropriate height for

each test and can be completely removed for easy cleaning. A Viton O-ring

prevents leakage.

•Cell body – provides a variable depth reservoir for the sample (semisolid,

solution, suspension, or emulsion) being tested.

Two additional tools are required to properly use the Enhancer Cell Assembly and

must be ordered separately:

•Adjustment tool – to move the adjustment plate.

•Alignment tool – to ensure the membrane is in proper contact with the

sample and the washer is properly centered.

This product is warranted to be free from manufacturing defects at the time of

delivery. Please report any problems upon receipt of merchandise to an Agilent

Customer Care Center. Contact information can be found www.agilent.com

under your country using the Contact Us link.

1Introduction

Enhancer Cell Operator’s Manual 9

Unpacking Your Enhancer Cell Assembly

1Carefully remove the Enhancer Cell Assembly.

2Ensure all of the following items were shipped with your Enhancer Cell:

If any item is damaged or missing, contact the Dissolution Systems Service

Department or your local Agilent representative for replacements.

•Enhancer Cell Assembly Operator’s Manual

•Retaining ring

•Washer

•Adjustment plate with O-ring

•Cell body

•Included if purchased separately:

•Adjustment tool

•Alignment tool

1Introduction

10 Enhancer Cell Operator’s Manual

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