Miltenyi Biotec MultiMACS X Manual de usuario

MultiMACS™ X

User manual

No part of this user manual may be reproduced, stored in a retrieval system, transmitted, published, or distributed in any form or by any means,

electronically, mechanically, by photocopying, microfilming, recording, or otherwise, without the prior written consent of Miltenyi Biotec; however,

notwithstanding the foregoing, the owners of the MultiMACS™ X may make copies solely for purposes of training personnel in the use and servicing of

the unit within their business or organization. Maximal care has been taken by Miltenyi Biotec in the preparation of this user manual. However, Miltenyi

Biotec shall not be liable for any technical or editorial errors or omissions contained herein or for incidental or consequential damages in connection with

the furnishing, performance, or use of this document. The information in this document is provided “as is” without warranty of any kind, and is subject to

change without notice. MACS, MultiMACS, and the Miltenyi Biotec logo are either registered trademarks or trademarks of Miltenyi Biotec and/or its

affiliates in various countries worldwide. All other trademarks mentioned in this document are the property of their respective owners and are used for

identification purposes only. Unless otherwise specifically indicated, Miltenyi Biotec products and services are for research use only and not for therapeutic

or diagnostic use.

MultiMACS™ X

User manual

Original instructions

Miltenyi Biotec B.V. & Co. KG

Friedrich-Ebert-Straße 68

51429 Bergisch Gladbach

Germany

Phone +49 2204 8306-0

Fax +49 2204 85197

macsde@miltenyi.com

www.miltenyibiotec.com

Read the chapter Important safety information and all

other information in this user manual before using the

instrument

Before using the MultiMACS™ X, read the chapter Important safety information and all other information

contained in this user manual, including any safety and operating instructions. Pay special attention to all

warnings displayed on the instrument. Failure to read and follow these guidelines could lead to improper or

incorrect usage and result in damage to the instrument. Improper usage could also cause severe personal injury,

death, unpredictable results, instrument malfunction, and premature wear to components shortening the

lifetime of the instrument. Such actions may void your warranty. Keep the user manual and any other safety and

operating instructions provided with the instrument in a safe place accessible to all users for future reference.

If you have a serious concern regarding the safe use of your instrument, contact your authorized Miltenyi Biotec

service provider or call Miltenyi Biotec Technical Support.

Content

Important safety information 7

Wichtige Sicherheitshinweise 15

Información importante de seguridad 25

Informations de sécurité importantes 33

1 Introduction 41

2 Installation 43

2.1 Components included in the delivery 43

2.2 Consumables 44

2.3 Accessories 45

3 Components of the MultiMACS X 47

3.1 The robotic arms of the MultiMACS X 48

3.1.1 The liquid handling arm (LiHa) 48

3.1.2 The robotic manipulator arm (RoMa) 48

3.2 Liquid containers 48

3.3 MultiMACS Cell24 Separator X, MACS Elution Station X, and MACS Elution Chamber X 48

3.4 The waste unit 49

3.5 Storage hotels 49

3.6 MultiMACS X Chill Racks 49

3.6.1 Reagent racks 49

3.6.2 Sample racks 49

3.7 The MultiMACS X work area 50

3.8 Control elements 50

3.8.1 Robot ON/OFF button 50

3.8.2 Pause button 50

3.8.3 Computer ON/OFF button 50

3.8.4 The status lamp 50

3.9 Options for customization 51

3.9.1 Steel needles 51

3.9.2 Hood integration 51

4 Startup and shutdown 53

4.1 Switch on the instrument 53

4.2 Log in 53

4.3 The user interface 55

4.4 Shutting down the instrument 56

5 Running a separation 57

5.1 Start a program 57

5.2 Quickstart 63

5.2.1 Select a program from the quickstart list 63

5.2.2 Add a program from the quickstart list 64

5.2.3 Remove programs from the quickstart list 64

6 Maintenance 67

6.1 Daily maintenance tasks 67

6.1.1 Perform a daily wash 67

6.1.2 Exchange the DiTi waste bag 69

6.1.3 Cleaning and inspection of DiTi cones (LiHa) 69

6.1.4 Tightening of the fixed tip lock nut (re-usable steel needles) 70

6.1.5 Tightening of syringe and plunger lock screws 70

6.1.6 Checking for leaks 71

6.1.7 Cleaning fixed tips (Re-usable steel needles) 71

6.1.8 Checking fixed tips for damage 71

6.2 Weekly maintenance tasks 72

6.2.1 Cleaning the worktable 72

6.2.2 Cleaning the acrylic safety panel 72

6.2.3 Cleaning the liquid containers 72

6.2.4 Cleaning the DiTi waste and wash station unit 72

6.2.5 System decontamination 74

6.3 Corrective maintenance 75

6.3.1 Initialization of the MultiMACS Cell24 Separator X in case of a power failure 75

6.3.2 Gripper check 75

6.4 Cleaning agents 75

7 Troubleshooting 77

7.1 Power failure 77

7.2 Improper initialization of the RoMa 77

7.3 Leakage of the liquid system 78

8 Technical data and specifications 79

8.1 Technical specifications of the MultiMACS X 79

8.2 Technical specifications of the MultiMACS Cell24 Separator X 82

8.3 Technical specifications of the MACS Elution Station X 82

8.4 EC/EU Declaration of Conformity 83

9 Technical support 85

10 Limited warranty 87

Important safety information

The MultiMACS X is designed for safe use when installed correctly, operated by professional laboratory

personnel, operated in accordance with general safety practices and the instructions in this user manual.

Warnings and precautions

The guidelines in this section explain the potential risk associated with operating this instrument and provide

important supplemental safety information to minimize the risks. Follow the instructions carefully to protect

yourself, others, and the equipment from potential hazards and create a safe work environment. Use this

instrument only as specified by the manufacturer to avoid damage of equipment and injury to personnel.

Always follow local working area safety instructions and laboratory policies as well as standards for health,

safety and prevention of accidents. Contact the local authorities governing electrical power supply, building

constructions, maintenance, or safety for more information about the safe installation and operation of the

instrument.

Hazard levels

Signal words are used to warn against hazardous situations and property damages. The following signal words

are used in this user manual.

or WARNING! indicates a hazardous situation that could result in serious injury or death.

or CAUTION! indicates a hazardous situation that could result in minor or moderate injury. It is also used

to warn against unsafe practices.

Safety symbols

SAFETY ALERT. RISK OF DANGER. THE DOCUMENTATION NEEDS TO BE CONSULTED IN ALL CASES

WHERE THIS SAFETY SYMBOL IS USED, IN ORDER TO FIND OUT THE NATURE OF THE POTENTIAL

HAZARD AND ANY ACTIONS THAT HAVE TO BE TAKEN.

RISK OF ELECTRIC SHOCK.

STRONG MAGNETIC FIELD.

PERSONS CARRYING PACEMAKERS OR ELECTRONIC MEDICAL IMPLANTS MUST MAINTAIN DISTANCE.

RISK OF CRUSHING AND SHEARING OF BODILY PARTS.

HAZARDOUS OPTICAL RADIATION.

IMPORTANT SAFETY INFORMATION

DEESFR

BIOHAZARD. RISK OF CONTAMINATION IF POTENTIALLY DANGEROUS BIOLOGICAL MATERIAL IS

USED.

PROTECTIVE CONDUCTOR TERMINAL. SYMBOL IS ATTACHED ON THE INSIDE OF THE INSTRUMENT.

INFORMATION FOR SERVICE PERSONNEL.

DISTURBANCE OF FUNCTIONS BY ELECTROMAGNETIC RF WAVES. DO NOT USE A CELLULAR PHONE.

FUSE.

WEEE.

READ THE USER MANUAL BEFORE USING THE INSTRUMENT.

DISCONNECT MAINS PLUG FROM ELECTRICAL OUTLET.

MANUFACTURER.

ORDER NUMBER.

TYPE NUMBER.

SERIAL NUMBER.

EUROPEAN CONFORMITY APPROVAL.

NRTL CERTIFICATION MARK: PRODUCT MEETS CONSENSUS-BASED STANDARDS OF SAFETY,

REQUIRED BY THE OCCUPATIONAL SAFETY/HEALTH ADMINISTRATION (OSHA), DETERMINED BY THE

NATIONALLY RECOGNIZED TESTING LABORATORIES (NRTL) TÜV SÜD.

Safety labels

Notice the hazard points and safety symbols of the instrument.

• Keep safety labels and safety markings clean and legible.

• Inspect the safety labels and safety markings regularly and replace them if they are not legible or identifiable

from a safe viewing distance.

• Contact Miltenyi Biotec for replacement labels.

IMPORTANT SAFETY INFORMATION

DEESFR

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